Since different fonts convey different feelings, it’s important you choose a font that matches your message. Your typeface must be congruent with your message. What kind of feeling are you trying to convey? Try out different fonts until you find a font that matches the mood you are trying to create.
For example, in his TED talk called “Lies, damned lies and statistics (about TED talks)” Sebastian Wernicke shared with the audience his statistical analysis on how to create the optimum TED talk. The talk was fun and lighthearted. Thus, he chose a font that would convey this mood. Check out a sample slide, as well as his full TED talk below: